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289. A methanogen hydrolase reveals the structure of archaeal peptidoglycan
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-yArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, revealing an unsuspected chemical structure of archaeal peptidoglycan that includes a previously unidentified sugar.
Nature Science
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